Publications: Laboratory Research

This is a list of papers and book chapters focused on our laboratory research efforts to assess the chemistry and bioactivity of medicinal plants.

Published and Accepted Research Articles (clinical, basic science, other) in Refereed Journals

  1. Quave, C.L., L.R.W. Plano, T. Pantuso, and B.C. Bennett (2008). Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence in MRSA. Journal of Ethnopharmacology 118: 418-428.
  2. Quave, C.L., L.R.W. Plano, and B.C. Bennett (2010) Quorum sensing inhibitors for Staphylococcus aureus from Italian medicinal plants. Planta Medica, 76: 1-8.
  3. Ordóñez, P.E., C.L. Quave, W.F. Reynolds, K.I. Varughese, B. Berry, O. Malagón, M.S. Smeltzer, and C.M. Compadre. (2011). Sesquiterpene lactones of Gynoxys verrucosa and their anti-MRSA activity. Journal of Ethnopharmacology 137(2):1055-1059.
  4. Quave, C.L., M.E. Carmona, C.M. Compadre, G. Hobby, H. Hendrickson, K. Beenken, and M.S. Smeltzer. (2012). Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS ONE 7(1): e28737.
  5. Hobby, G., C.L. Quave, K. Nelson, C. Compadre, K. Beenken, and M.S. Smeltzer. (2012) Quercus cerris extracts limit Staphylococcus aureus biofilm formation. Journal of Ethnopharmacology. 144(3): 812-815.
  6. Talekar, S.J., S. Chochua, K. Nelson, K.P. Klugman, C.L. Quave and J.E. Vidal (2014). 220D-F2 from Rubus ulmifolius kills Streptococcus pneumoniae planktonic cells and pneumococcal biofilms. PLoS ONE 9(5): e97314.
  7. Quave, C.L., J.T. Lyles, J.S. Kavanaugh, K. Nelson, C.P. Parlet, H.A. Crosby, K.P. Heilmann, A.R. Horswill. (2015) Castanea sativa (European Chestnut) leaf extracts rich in ursene and oleanene derivatives block Staphylococcus aureus virulence and pathogenesis without detectable resistance. PLoS ONE 10(8): e0136486. doi:10.1371/journal.pone.0136486
  8. Hadjari, A., B. Mustafa, D. Nebija, E. Miftari, C.L. Quave, J. Novak. (2015) Chemical composition of Juniperus communis L. cone essential oil and its variability among wild populations in Kosovo. Chemistry and Biodiversity, 12: 1706–1717. doi: 10.1002/cbdv.201400439
  9. Hajdari, A., B. Mustafa, G. Ahmeti, B. Pulaj, B. Lukas, A. Ibraliu, G. Stefkov, C.L. Quave, J. Novak. (2015). Essential oil variation among natural populations of Pinus mugo Turra in Kosovo. SpringerPlus 4:828 DOI 10.1186/s40064-015-1611-5
  10. Pulaj, B., B. Mustafa, K. Nelson, C.L. Quave, A. Hajdari. (2016) Chemical composition and in vitro antibacterial activity of Pistacia terebinthus essential oils derived from wild populations in Kosovo. BMC Complementary and Alternative Medicine 16:147. DOI 10.1186/s12906-016-1135
  11. Nelson, K.N., J.T. Lyles, T. Li, A. Saitta, E. Addie-Noye, P. Tyler, C.L. Quave. (2016) Anti-acne activity of Italian medicinal plants used for skin infection. Frontiers in Pharmacology 7:435.
  12. Muhs, A., T. Lyles, C.P. Parlet, K. Nelson, J.S. Kavanaugh, A. R. Horswill, C.L. Quave. (2017) Virulence inhibitors from Brazilian Peppertree block quorum sensing and abate dermonecrosis in skin infection models. Scientific Reports 7: 42275 doi:10.1038/srep42275
  13. Fontaine, B.M., K. Nelson, J.T. Lyles, P.B. Jariwala, J. M. Garcia-Rodriguez, C.L. Quave, E.E. Weinert. (2017) Identification of Ellagic Acid Rhamnoside as a Bioactive Component of a Complex Botanical Extract. Frontiers in Microbiology 8:496 doi: 10.3389/fmicb.2017.00496
  14. Lyles, J.T., P. Tyler, E.J. Bradbury, K. Nelson, C.F. Brown, S.T. Pierce, C.L. Quave (2017). Comparative Phytochemical Analysis of Schisandra spp. (Chinese and Bay Starvine) Journal of Dietary Supplements, 1-13. doi: 10.1080/19390211.2017.1304483
  15. Lavoie, S., D. Brumley, T.S. Alexander, C. Jasmin, F.A. Carranza, K. Nelson, C.L. Quave, and J. Kubanek. (2017) Iodinated meroditerpenes from a red alga Callophycus sp. The Journal of Organic Chemistry DOI: 10.1021/acs.joc.7b00096
  16. De la Parra, J. and C.L. Quave. (2017). Ethnophytotechnology: Harnessing the power of ethnobotany with biotechnology. Trends in Biotechnology S0167-7799(17)30170-1. doi: 10.1016/j.tibtech.2017.07.003
  17. Lyles, J.T., A. Kim, K. Nelson, A. Bullard-Roberts, A. Hajdari, B. Mustafa, C.L. Quave. (2017) The chemical and antibacterial evaluation of St. John’s Wort oil macerates used in Kosovar traditional medicine. Frontiers in Microbiology https://doi.org/10.3389/fmicb.2017.01639

Review Articles

  1. Quave, C.L. and A.R. Horswill. (2014). Flipping the switch: Tools for detecting small molecule inhibitors of staphylococcal virulence. Frontiers in Microbiology. 5(706):1-10. doi: 10.3389/fmicb.2014.00706

Published Abstracts

  1. Quave, C.L., LR.W. Plano, and B.C. Bennett (2008). Quorum sensing inhibiting activity of Schinus terebinthifolius Radii (Anacardiaceae) extracts against MRSA. Planta Medica 74: P-43.
  2. Quave, C.L. and M.S. Smeltzer. (2009). Anti-Biofilm Activity of Marrubium vulgare (Lamiaceae) Extract on MRSA. Planta Medica 75: P-96.
  3. Ordoñez, P., C.L. Quave, W.F. Reynolds, K.I. Varughese, B.B. Malagon, M.S. Smeltzer, and C.M. Compadre. (2011). Sesquiterpene lactones of Gnoxys verrucosa and their anti-MRSA activity. Planta Medica 77: P-34.
  4. Hobby, G. C.L. Quave, C. Compadre, K. Beenken, and M.S. Smeltzer. (2011). Inhibition of biofilm formation in Staphylococcus aureus Isolates by Quercus cerris extracts. Planta Medica 77: P-35.
  5. Quave, C.L., C. Compadre, H. Hendrickson, K. Beenken, M.S. Smeltzer. (2011). Staphylococcus aureus biofilm inhibition by a phenolic glycoside-rich extract of Rubus ulmifolius. Planta Medica 77: P-33.
  6. Quave, C.L. (2012). Ethnobotanical clues for the discovery of natural product mediators of microbial pathogenesis. Planta Medica 78: P-46. DOI: 10.1055/s-0032-1320593
  7. Quave, C., J. Lyles, K. Nelson, JS Kavanaugh, C. Parlet, H. Crosby and A. Horswill. (2015). Secrets from the past: Natural products and the future of topical anti-infectives. Journal of Investigative Dermatology 135(S1): S94 (P545).
  8. Quave, C.L. (2016) Answering the call to arms: Tools for assessing the anti-infective potential of natural products in a time of rising antibiotic resistance. Planta Medica 82 – OA38. DOI: 1055/s-0036-1578608
  9. Lyles, J.T., J.S. Kavanaugh, K. Nelson, C.P. Parlet, H.A. Crosby, K.P. Heilmann, A.R. Horswill, C.L. Quave. (2016) Structure elucidation of ursene and oleanene derivatives from Castanea sativa (European Chestnut) that inhibit Staphylococcus aureus virulence and pathogenesis. Planta Medica 82- PC44. DOI: 10.1055/s-0036-1578746
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