Short Research Description
The Quave lab applies the ethnobotanical approach to drug discovery. We examine botanical natural products for anti-virulence activity in treatment of multidrug-resistant bacterial infections. This involves field research to document traditional therapies for skin infections, collection of plants for chemical extraction, and bioassay-guided fractionation strategies to isolate novel drugs. You can check the stats on our work in Google Scholar. As of July 2023, Dr. Quave has an H-index of 45, i-10 of 90, and >6,800 total citations of work from her lab.
† Awards, honors, or high citations associated with the publication; ‡ Description of my contribution if I am neither first nor last author (per Emory guidelines); ** Students/postdocs/medical residents I have trained, undergraduate researchers are underlined; # Equal contributions.
Published and Accepted Review Articles in Peer Reviewed Journals:
- Woo, S., L. Marquez**, W.J. Crandall**, C.J. Risener**, C.L. Quave. (2023) Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022. Natural Product Reports. DOI: 10.1039/d2np00090c [Link]
- Vardeman, E.**, J.T. Lyles, C. L. Quave. (2022). The genus Rudbeckia: A critical review of its traditional medicinal uses, phytochemistry, and pharmacology. Journal of Herbal Medicine. 31:100530. [Link]
- Munroe, D., M.A. Moore, J.P. Bonnet, K. Rastorguieva, J.S. Mascaro, L.W. Craighead, C.I. Haack, C.L. Quave, S.H. Bergquist. (2021). Development of Culinary and Self-Care Programs in Diverse Settings: Theoretical Considerations and Available Evidence. American Journal of Lifestyle Medicine https://doi.org/10.1177/15598276211031493 [Link]
- Chassagne, F. **#, T. Samarakoon#, G. Porras**, J.T. Lyles, M. Dettweiler, L. Marquez**, A.M. Salam**, S. Shabih**, D. Raschid Farrokhi**, C.L. Quave. (2021). A Systematic Review of Plants with Antibacterial Activities: A Taxonomic Perspective. Frontiers in Pharmacology doi: 10.3389/fphar.2020.586548 [Link]
- Porras, G.**#, F. Chassagne**#, J.T. Lyles#, L. Marquez**, M. Dettweiler, M. Salam**, T. Samarakoon, S. Shabih**, D. Raschid Farrokhi**, and C.L. Quave. (2020) Ethnobotany and the Role of Plant Natural Products in Antibiotic Discovery. Chemical Reviews http://dx.doi.org/10.1021/acs.chemrev.0c00922 [Link]
- Howes, M.J.R., C.L. Quave, J. Collemare, E.C. Tatsis, D. Twilley, E. Lulekal, A. Farlow, L. Li, M.E. Cazar, D.L. Leaman, T. A.K. Prescott, W. Milliken, C. Martin, M. De Canha, N. Lall, H. Qin, B. Walker, C. Vásquez-Londoño, B. Allkin, M.S.J. Simmonds, E. Bell, A. Battison, J. Felix, F. Forest, C. Williams, E.N. Lughadha. (2020) Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi. Plants, People, Planet https://doi.org/10.1002/ppp3.10138 [Link]
- Marquez, L.** and C.L. Quave. (2020). Prevalence and therapeutic challenges of fungal drug resistance: Role for plants in drug discovery. Antibiotics 9, 150. [Link]
- Pintas, S.** and C.L. Quave. (2019). A review of botanicals exhibiting antifungal activity against Malessezia spp. implicated in common skin conditions. Current Dermatology Reports https://doi.org/10.1007/s13671-019-00274-1 [Link]
- Quave, C.L. (2018). Wound healing with botanicals: A review and future perspectives. Current Dermatology Reports https://doi-org.proxy.library.emory.edu/10.1007/s13671-018-0247-4 1-9. [Link]
- Salam, A.** and C.L. Quave (2018). Opportunities for plant natural products in infection control. Current Opinion in Microbiology 45: 189-194 [Link]
- Salam, A.** and C.L. Quave. (2018) Targeting virulence in Staphylococcus aureus by chemical inhibition of the accessory gene regulator system in vivo. mSphere 3(1). DOI: 10.1128/mSphere.00500-17 [Link]
- De la Parra, J.** and C.L. Quave. (2017). Ethnophytotechnology: Harnessing the power of ethnobotany with biotechnology. Trends in Biotechnology S0167-7799(17)30170-1. doi: 10.1016/j.tibtech.2017.07.003 [Link]
- Bonchak, J.G.**, S. Thareja, S.C. Chen, C.L. Quave. (2017). Botanical Complementary and Alternative Medicine for Pruritis: A Systematic Review. Current Dermatology Reports 6(4): 248-255 https://doi.org/10.1007/s13671-017-0200-y [Link]
- Quave, C.L. and A.R. Horswill. (2014). Flipping the switch: Tools for detecting small molecule inhibitors of staphylococcal virulence. Frontiers in Microbiology. 5(706):1-10. doi: 10.3389/fmicb.2014.00706 [Link]
- Sõukand, R., C.L. Quave, A. Pieroni, M. Pardo-de-Santayana, J. Tardío, R. Kalle, Ł. Łuczaj, I. Svanberg, V. Kolosova, L. Aceituno-Mata, G. Menendez, I. Kołodziejska-Degórska, E. Pirożnikow, R. Petkevičius, A. Hajdari, B. Mustafa. (2013). Plants used for making recreational tea in Europe: A review based on specific research sites. Journal of Ethnobiology and Ethnomedicine. 9:58. [Link]
- ‡ Contributed to literature review, data analysis, writing and revising the article.
- Quave, C.L., M. Pardo-de-Santayana, and A. Pieroni (2012) Medical ethnobotany in Europe: from field ethnography to a more culturally-sensitive evidence-based CAM? Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2012/156846. [Link]
- Rose, J., C.L. Quave, and G. Islam. (2012) The four-sided triangle of ethics in bioprospecting: Pharmaceutical business, international politics, socio-environmental responsibility and the importance of local stakeholders. Ethnobiology and Conservation.1:3. [Link]
- ‡ Contributed to literature review, writing and revising the article.
- McCullough, I.**, Kucheryavyy**, and C.L. Quave (2012). Immune modulation as a tool in promoting recovery from traumatic brain injury and stroke. Journal of Undergraduate Research and Scholarly Excellence 3 (1): 6-10. [Link]
- Quave, C.L. (1999). Paradise lost? Ethnobotany and its relevance to tropical forest conservation in Amazonia. The Emory Anthropologist: A Journal of Undergraduate Research 4: 24-30.
Op-Eds, Essays, and Perspectives:
- Quave, C.L. (March/April 2022) Searching for nature’s medicines. Spirituality and Health. [March/April 2022 issue in print] [Link]
- Quave, C.L. (December 2021). The Plant Hunter. One scientist’s journey finding medicine, ethnobotany and the pharmacological potential of plants. The Ethnobotanical Assembly. Issue 8. Winter 2021. [online] [Link]
- Quave, C.L. (December 2021) 7 essential medicinal mints you can grow and use in teas. Spirituality and Health [online] [Link]
- Quave, C.L. (November 20, 2021). Hunting for Medicines Hidden in Plants. The Wall Street Journal [online and in print] [Link]
- Quave, C.L. (November 18, 2021) Drugs from nature: ethnobotany as a strategy for antimicrobial drug discovery. Biotechniques [online and in print] [Link]
- Quave, C.L. (November 15, 2021) Wild Plants and the Food-Medicine Continuum. Herbal History Research Network [online] [Link]
- Quave, C.L. (Summer 2021) My Pandemic Zoo. Emory Medicine Magazine [online and in print]
- Quave, C.L. Oleandrin is a deadly plant poison, not a COVID-19 cure. The Conversation [Link]
- Vandebroek, I., A. Pieroni, J.R. Stepp, N. Hanazaki , A. Ladio, R.R. Nóbrega Alves, D. Picking, R. Delgoda, A. Maroyi, T. van Andel, C.L. Quave, N.Y. Paniagua-Zambrana, R.W. Bussmann, G. Odonne, A.M. Abbasi, U.P. Albuquerque, J. Baker, S. Kutz, S. Timsina, M. Shigeta, T.P.R. de Oliveira, J.A. Hurrell, P.M. Arenas, J.P. Puentes, J. Hugé, Y. Yeşil, L.J. Pierre, T.M. Olango, F. Dahdouh-Guebas (2020) Reshaping the future of ethnobiology research after the Covid-19 pandemic. Nature Plants https://doi-org.proxy.library.emory.edu/10.1038/s41477-020-0691-6 [Link]
- Walker, K., N. Canales, C.L. Quave (March 2020) No, cinchona bark is not a cure for coronavirus. The Conversation [Link]
- Quave, C.L. (January 2019) Fieldwork with Family… and a Fake Leg. American Society of Pharmacognosy Newsletter, Winter 2018 Issue, 54(4): 31-33. [Link]
- Quave, C.L. (October 2017) Green fingers: How much untapped potential do plants have for both discovering and manufacturing drugs? The Medicine Maker magazine. [Link]
- Rose, G. Islam, C.L. Quave (May 7, 2012). Global controversies in bioprospecting. Caros amigos (Brazilian newspaper)
Editorials and Invited Commentaries:
- Vandebroek, I., A. Pieroni, J.R. Stepp, N. Hanazaki , A. Ladio, R.R. Nóbrega Alves, D. Picking, R. Delgoda, A. Maroyi, T. van Andel, C.L. Quave, N.Y. Paniagua-Zambrana, R.W. Bussmann, G. Odonne, A.M. Abbasi, U.P. Albuquerque, J. Baker, S. Kutz, S. Timsina, M. Shigeta, T.P.R. de Oliveira, J.A. Hurrell, P.M. Arenas, J.P. Puentes, J. Hugé, Y. Yeşil, L.J. Pierre, T.M. Olango, F. Dahdouh-Guebas (2020) Reshaping the future of ethnobiology research after the Covid-19 pandemic. Nature Plants [Link]
- Quave, C.L. (2018) Deconstructing Eden. Nature Plants 4: 978 https://doi.org/10.1038/s41477-018-0326-3 [Link]
- Greenway, A. and C.L. Quave (2018). Anti-infectives derived from botanical natural products: an interview with Cassandra Quave. Future Microbiology https://doi.org/10.2217/fmb-2018-0204 [Link]
- Muhs, A.** and C.L. Quave. (2017). Brazilian Peppertree: From noxious weed to a source of medicine? Food and Agriculture Organization of the United Nations (FAO) Non-wood Forest Product Update. Issue 11. [Link]
- Quave, C.L. (2016) Commentary on: “The adaptive nature of culture. A cross-cultural analysis of the returns of local environmental knowledge in three indigenous societies” by V. Reyes-García, M. Guèze, I. Díaz-Reviriego, R. Duda, Á. Fernández-Llamazares, S. Gallois, L. Napitupulu, M. Orta-Martínez and A. Pyhälä. Current Anthropology 57(6):761-784.
- Quave, C.L., K. Barfield, N. Ross, and K.C. Hall (2015). Editorial: The Open Science Network in Ethnobiology: Growing the Influence of Ethnobiology. Ethnobiology Letters. 6:1-4. [Link]
- Pieroni, A., M. Pardo-de-Santayana, F. Firenzuoli, and C.L. Quave. (2013). Editorial: The European Heritage of Folk Medicines and Medicinal Foods: Its Contribution to the CAMs of Tomorrow. Evidence Based Complementary and Alternative Medicine. Volume 2013, Article ID 827521, http://dx.doi.org/10.1155/2013/827521 [Link]
- Antonelli, A., C. Fry, R.J. Smith, M.S.J. Simmonds, P.J. Kersey, H.W. Pritchard, M.S. Abbo, C. Acedo, J. Adams, A.M. Ainsworth, B. Allkin, W. Annecke, S.P. Bachman, K. Bacon, S. Bárrios, C. Barstow, A. Battison, E. Bell, Bensusan, M.I. Bidartondo, R.J. Blackhall-Miles, B. Bonglim, J.S. Borrell, F.Q. Brearley, E. Breman, R.F.A. Brewer, J. Brodie, R. Cámara-Leret, R. Campostrini Forzza, P. Cannon, M. Carine, J. Carretero, T.R. Cavagnaro, M.-E. Cazar, T. Chapman, M. Cheek, C. Clubbe, C. Cockel, J. Collemare, A. Cooper, A.I. Copeland, M. Corcoran, C. Couch, C. Cowell, P. Crous, M. da Silva, G. Dalle, D. Das, J.C. David, L. Davies, N. Davies, M.N. De Canha, E.J. de Lirio, S. Demissew, M. Diazgranados, J. Dickie, T. Dines, B. Douglas, G. Dröge, M.E. Dulloo, R. Fang, A. Farlow, K. Farrar, M.F. Fay, J. Felix, F. Forest, L.L. Forrest, T. Fulcher, Y. Gafforov, L.M. Gardiner, G. Gâteblé, E. Gaya, B. Geslin, S.C. Gonçalves, C.J.N. Gore, R. Govaerts, B. Gowda, O.M. Grace, A. Grall, D. Haelewaters, J.M. Halley, M.A. Hamilton, A. Hazra, T. Heller, P.M. Hollingsworth, N. Holstein, M.-J.R. Howes, M. Hughes, D. Hunter, N. Hutchinson, K. Hyde, J. Iganci, M. Jones, L.J. Kelly, P. Kirk, H. Koch, I. Krisai-Greilhuber, N. Lall, M.K. Langat, D.J. Leaman, T.C. Leão, M.A. Lee, I.J. Leitch, C. Leon, E. Lettice, G.P. Lewis, L. Li, H. Lindon, J.S. Liu, U. Liu, T. Llewellyn, B. Looney, J.C. Lovett, Ł. Łuczaj, E. Lulekal, S. Maggassouba, V. Malécot, C. Martin, O.R. Masera, E. Mattana, N. Maxted, C. Mba, K.J. McGinn, C. Metheringham, S. Miles, J. Miller, W. Milliken, J. Moat, J., P.G.P. Moore, M.P. Morim, G.M. Mueller, H. Muminjanov, R. Negrão, E. Nic Lughadha, N. Nicolson, T. Niskanen, R. Nono Womdim, A. Noorani, M. Obreza, K. O’Donnell, R. O’Hanlon, J.-M. Onana, I. Ondo, S. Padulosi, A. Paton, T. Pearce, O.A. Pérez Escobar, A. Pieroni, S. Pironon, T.A.K. Prescott, Y.D. Qi, H. Qin, C.L. Quave, L. Rajaovelona, H. Razanajatovo, P.B. Reich, E. Rianawati, T.C.G. Rich, S.L. Richards, M.C. Rivers, A. Ross, F. Rumsey, M. Ryan, P. Ryan, S. Sagala, M.D. Sanchez, S. Sharrock, K.K. Shrestha, J. Sim, A. Sirakaya, H. Sjöman, E.C. Smidt, D. Smith, P. Smith, S.R. Smith, A. Sofo, N. Spence, A. Stanworth, K. Stara, P.C. Stevenson, P. Stroh, L.M. Suz, E.C. Tatsis, L. Taylor, B. Thiers, I. Thormann, C. Trivedi, D. Twilley, A.D. Twyford, T. Ulian, T. Utteridge, V. Vaglica, C. Vásquez-Londoño, J. Victor, J. Viruel, B.E. Walker, K. Walker, A.Walsh, M. Way, J. Wilbraham, P. Wilkin, T. Wilkinson, C. Williams, D. Winterton, K.M. Wong, N. Woodfield-Pascoe, J. Woodman, L. Wyatt, R. Wynberg, B.G. Zhang (2020). State of the World’s Plants and Fungi 2020. Royal Botanic Gardens, Kew. DOI: https://doi.org/10.34885/172 [Link]